Researchers decode what makes brown rice healthy
[Jan. 20, 2023: Ryoko Mimura, Okayama University]
As a regular addition to the diet, brown rice can help reduce body weight, lower cholesterol, and suppress inflammation. (CREDIT: Creative Commons)
Asian diets feature rice as a staple grain, contributing towards nearly 90% of the world’s rice consumption. Brown rice, in particular, is known to have several health benefits. As a regular addition to the diet, it can help reduce body weight, lower cholesterol, and suppress inflammation.
The ability of brown rice to neutralize reactive oxygen species and prevent cellular damage is vital to many of its health-promoting effects. Although previous studies have shown that the antioxidant compounds in brown rice can protect cells against oxidative stress, knowledge regarding which major compound contributes towards these beneficial properties has long remained a mystery.
In a recent study led by Professor Yoshimasa Nakamura from the Graduate School of Environmental and Life Science, Okayama University, researchers from Japan have identified cycloartenyl ferulate (CAF) as the main “cytoprotective” or cell-protecting compound in brown rice. CAF is a unique compound owing to its hybrid structure.
As Professor Nakamura explains, “CAF is a hybrid compound of polyphenol and phytosterol and is expected to be a potent bioactive substance with various pharmacological properties, such as antioxidant effect and blood fat-lowering effect.”
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The study published in the International Journal of Molecular Sciences, was co-authored by Hongyan Wu, from Dalian Polytechnic University, and Toshiyuki Nakamura, from the Graduate School of Environmental and Life Science at Okayama University. In it, the researchers provide evidence of CAF’s antioxidant properties by demonstrating that it can protect cells from stress caused by hydrogen peroxide.
Although hydrogen peroxide is a by-product of a cell’s metabolic processes, abnormal amounts of the compound can be toxic to cells and cause irreversible damage.
Treatment of cells with CAF increased their resistance to toxic stress induced by hydrogen peroxide. Moreover, CAF provided greater protection from hydrogen peroxide-induced stress compared to alpha-tocopherol and gamma-tocopherol, two other prominent antioxidant compounds that were earlier speculated to be major contributors to the antioxidant capacity of brown rice.
Several fat-soluble compounds present in brown rice have antioxidant capacity but are present in small quantities. Cycloartenyl ferulate, a relatively abundant molecule, has been revealed as the major compound responsible for several health benefits of brown rice. (CREDIT: Yoshimasa Nakamura)
According to the study’s estimates, the amount of CAF in the whole grain of brown rice is five-fold higher than that of other antioxidant compounds found in brown rice. Further, CAF increases the concentration of heme oxygenase-1 or HO-1, an enzyme that facilitates the production of antioxidants.
“We demonstrated here that CAF significantly increased the mRNA level of HO-1, the small molecular weight antioxidant-producing enzyme, at concentrations similar to that required for cytoprotective effects in resistance to oxidative damage,” Professor Nakamura explains.
Modulating effect of CAF on the gene expression of cytoprotective proteins and the hydrogen peroxide-induced cytotoxicity in Hepa1c1c7 cells. (CREDIT: Journal of Molecular Sciences)
The researchers further explored this mechanism of action through experiments where blocking HO-1 activity using inhibitors reduced the antioxidant effect of CAF considerably. The high abundance and unique mechanism of action are evidence that CAF is the major contributing antioxidant in brown rice.
Through this study, the researchers have not only uncovered the secret to the health benefits of brown rice, but also locked down on the component that is majorly responsible for these benefits. This will allow the use of CAF in the development of better novel supplements and food products focused on consumer health.
Modulating effects of CAF on the nuclear factor erythroid 2-related factor 2 (Nrf2) level. (CREDIT: Journal of Molecular Sciences)
As an optimistic Professor Nakamura observes, “Our study can help in the development of new functional foods and supplements based on the functionality of CAFs, like CAF-based nutraceuticals.”
Although, with such naturally occurring health benefits, brown rice still very much looks to be on the menu!
For more science news stories check out our New Discoveries section at The Brighter Side of News.
Note: Materials provided above by Okayama University. Content may be edited for style and length.
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